› 1shf

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF THE SH3 DOMAIN IN HUMAN FYN; COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SH3 DOMAINS IN TYROSINE KINASES AND SPECTRIN

Released:
DOI: 10.2210/pdb1shf/pdb
PDB entry 1shf coloured by chain, front view.
PDB entry 1shf coloured by chain, side view.
PDB entry 1shf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.
Noble ME, Musacchio A, Saraste M, Courtneidge SA, Wierenga RK
EMBO J 12 2617-24 (1993)
PMID: 7687536

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138973 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chains: A, B
Molecule details ›
Chains: A, B
Length: 59 amino acids
Theoretical weight: 6.74 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P06241 (Residues: 84-142; Coverage: 11%)
Gene name: FYN
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 73.7Å b: 48.6Å c: 43Å
α: 90° β: 98.1° γ: 90°
R-values:
R R work R free
0.18 0.18 not available
Expression system: Not provided

Quick links

Citations

15 review citations

Regulation, substrates and functions of src.
Brown et al. (1996)
14 more

54 mentions without citation

Characterization of the fast dynamics of protein amino acid side chains using NMR relaxation in solution.
Igumenova et al. (2006)
53 more