Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140188 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hepatocyte growth factor beta chain
Molecule details ›
Chain: A
Length: 234 amino acids
Theoretical weight: 26.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 234 amino acids
Theoretical weight: 26.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P14210 (Residues: 495-728; Coverage: 34%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Hepatocyte growth factor receptor
Molecule details ›
Chain: B
Length: 551 amino acids
Theoretical weight: 62.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Structure domains:
Length: 551 amino acids
Theoretical weight: 62.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P08581 (Residues: 25-567; Coverage: 40%)
Sequence domains:
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
CHESS BEAMLINE A1
Spacegroup:
P21212
Expression systems:
- Escherichia coli
- Spodoptera frugiperda
