› 1sk4

X-ray diffraction
1.65Å resolution

crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha

Released:
DOI: 10.2210/pdb1sk4/pdb
PDB entry 1sk4 coloured by chain, front view.
PDB entry 1sk4 coloured by chain, side view.
PDB entry 1sk4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha.
Guan R, Malchiodi EL, Wang Q, Schuck P, Mariuzza RA
J Biol Chem 279 31873-82 (2004)
PMID: 15140887

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-188615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidoglycan recognition protein 3 Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 18.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96LB9 (Residues: 179-341; Coverage: 50%)
Gene names: PGLYRP3, PGRPIA
Sequence domains: N-acetylmuramoyl-L-alanine amidase
Structure domains: Peptidoglycan recognition protein-like

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X26C
Spacegroup: P3221
Unit cell:
a: 64.464Å b: 64.464Å c: 63.996Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.196 0.212
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences.
Royet et al. (2007)
6 more

8 mentions without citation

The peptidoglycan recognition proteins (PGRPs).
Dziarski et al. (2006)
7 more