› 1skx

X-ray diffraction
2.8Å resolution

Structural Disorder in the Complex of Human PXR and the Macrolide Antibiotic Rifampicin

Released:
DOI: 10.2210/pdb1skx/pdb
PDB entry 1skx coloured by chain, front view.
PDB entry 1skx coloured by chain, side view.
PDB entry 1skx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.
Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR
Mol Endocrinol 19 1125-34 (2005)
PMID: 15705662

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 1 group I member 2 Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 36.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75469 (Residues: 130-431; Coverage: 70%)
Gene names: NR1I2, PXR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand RFP 1 x RFP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 91.537Å b: 91.537Å c: 85.504Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.306 0.218 0.266
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.
Tolson et al. (2010)
26 more

28 mentions without citation

CAR and PXR: the xenobiotic-sensing receptors.
Timsit et al. (2007)
27 more