› 1sl5

X-ray diffraction
1.8Å resolution

Crystal Structure of DC-SIGN carbohydrate recognition domain complexed with LNFP III (Dextra L504).

Released:
DOI: 10.2210/pdb1sl5/pdb
PDB entry 1sl5 coloured by chain, front view.
PDB entry 1sl5 coloured by chain, side view.
PDB entry 1sl5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR.
Guo Y, Feinberg H, Conroy E, Mitchell DA, Alvarez R, Blixt O, Taylor ME, Weis WI, Drickamer K
Nat Struct Mol Biol 11 591-8 (2004)
PMID: 15195147

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192443 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
CD209 antigen Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 16.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NNX6 (Residues: 250-388; Coverage: 34%)
Gene names: CD209, CLEC4L
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

Carbohydrate polymer : NEW Components: GAL, NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand CA 2 x CA
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21212
Unit cell:
a: 72.57Å b: 55.37Å c: 29.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.179 0.223
Expression system: Escherichia coli

Quick links

Citations

72 review citations

The C-type lectin-like domain superfamily.
Zelensky et al. (2005)
71 more

20 mentions without citation

From carbohydrate leads to glycomimetic drugs.
Ernst et al. (2009)
19 more