› 1sla

X-ray diffraction
2.45Å resolution

X-RAY CRYSTALLOGRAPHY REVEALS CROSSLINKING OF MAMMALIAN LECTIN (GALECTIN-1) BY BIANTENNARY COMPLEX TYPE SACCHARIDES

Released:
DOI: 10.2210/pdb1sla/pdb
PDB entry 1sla coloured by chain, front view.
PDB entry 1sla coloured by chain, side view.
PDB entry 1sla coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides.
Bourne Y, Bolgiano B, Liao DI, Strecker G, Cantau P, Herzberg O, Feizi T, Cambillau C
Nat Struct Biol 1 863-70 (1994)
PMID: 7773775

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145659 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 134 amino acids
Theoretical weight: 14.63 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P11116 (Residues: 2-135; Coverage: 99%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P6322
Unit cell:
a: 106.9Å b: 106.9Å c: 119.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.2 not available
Expression system: Not provided

Quick links

Citations

27 review citations

Animal lectins.
Gabius HJ. (1997)
26 more

4 mentions without citation

Structural insights into what glycan arrays tell us about how glycan-binding proteins interact with their ligands.
Taylor et al. (2009)
3 more