› 1smo

X-ray diffraction
1.47Å resolution

Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .

Released:
DOI: 10.2210/pdb1smo/pdb
PDB entry 1smo coloured by chain, front view.
PDB entry 1smo coloured by chain, side view.
PDB entry 1smo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A.
Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wüthrich K, Wilson IA
J Mol Biol 342 1237-48 (2004)
PMID: 15351648

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192470 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Triggering receptor expressed on myeloid cells 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 119 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NP99 (Residues: 21-139; Coverage: 56%)
Gene name: TREM1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand TLA 1 x TLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P61
Unit cell:
a: 110.937Å b: 110.937Å c: 46.835Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.193 0.206
Expression system: Escherichia coli

Quick links

Citations

15 review citations

The TREM receptor family and signal integration.
Klesney-Tait et al. (2006)
14 more

6 mentions without citation

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
Kober et al. (2016)
5 more