› 1soq

X-ray diffraction
2.1Å resolution

Crystal structure of the transthyretin mutant A108Y/L110E solved in space group C2

Released:
DOI: 10.2210/pdb1soq/pdb
PDB entry 1soq coloured by chain, front view.
PDB entry 1soq coloured by chain, side view.
PDB entry 1soq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The beta-strand D of transthyretin trapped in two discrete conformations.
Hörnberg A, Olofsson A, Eneqvist T, Lundgren E, Sauer-Eriksson AE
Biochim Biophys Acta 1700 93-104 (2004)
PMID: 15210129

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 13.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: C2
Unit cell:
a: 101.287Å b: 67.524Å c: 80.978Å
α: 90° β: 112.59° γ: 90°
R-values:
R R work R free
0.212 0.21 0.246
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Amyloid formation by globular proteins under native conditions.
Chiti et al. (2009)
10 other articles

1 mention without citation

Rapid and accurate prediction and scoring of water molecules in protein binding sites.
Ross et al. (2012)