› 1sqt

X-ray diffraction
1.9Å resolution

Substituted 2-Naphthamidine Inhibitors of Urokinase

Released:
DOI: 10.2210/pdb1sqt/pdb
PDB entry 1sqt coloured by chain, front view.
PDB entry 1sqt coloured by chain, side view.
PDB entry 1sqt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
Wendt MD, Geyer A, McClellan WJ, Rockway TW, Weitzberg M, Zhao X, Mantei R, Stewart K, Nienaber V, Klinghofer V, Giranda VL
Bioorg Med Chem Lett 14 3063-8 (2004)
PMID: 15149645

Function and Biology Details

Reaction catalysed: 
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133249 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urokinase-type plasminogen activator chain B Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 27.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00749 (Residues: 179-423; Coverage: 60%)
Gene name: PLAU
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand UI3 1 x UI3
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 55.16Å b: 53Å c: 82.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.236 0.236
Expression system: Spodoptera frugiperda

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Citations

2 review citations

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Wyganowska-Świątkowska et al. (2019)
1 more

10 mentions without citation

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Guedes et al. (2021)
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