› 1svc

X-ray diffraction
2.6Å resolution

NFKB P50 HOMODIMER BOUND TO DNA

Released:
DOI: 10.2210/pdb1svc/pdb
PDB entry 1svc coloured by chain, front view.
PDB entry 1svc coloured by chain, side view.
PDB entry 1svc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the NF-kappa B p50 homodimer bound to DNA.
Müller CW, Rey FA, Sodeoka M, Verdine GL, Harrison SC
Nature 373 311-7 (1995)
PMID: 7830764

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114617 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Nuclear factor NF-kappa-B p50 subunit Chain: P
Molecule details ›
Chain: P
Length: 365 amino acids
Theoretical weight: 41.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P19838 (Residues: 2-39, 40-365; Coverage: 38%)
Gene name: NFKB1
Sequence domains:
Structure domains:
DNA (5'-D(*AP*GP*AP*TP*GP*GP*GP*GP*AP*AP*TP*CP*CP*CP*CP*TP*A P*GP*A)-3') Chain: D
Molecule details ›
Chain: D
Length: 19 nucleotides
Theoretical weight: 5.88 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 137Å b: 137Å c: 57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.286
Expression system: Not provided

Quick links

Citations

78 review citations

The NF-kappa B and I kappa B proteins: new discoveries and insights.
Baldwin AS. (1996)
77 more

63 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
62 more