› 1t1f

X-ray diffraction
2.75Å resolution

Crystal Structure of Native Antithrombin in its Monomeric Form

Released:
DOI: 10.2210/pdb1t1f/pdb
PDB entry 1t1f coloured by chain, front view.
PDB entry 1t1f coloured by chain, side view.
PDB entry 1t1f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
Johnson DJ, Langdown J, Li W, Luis SA, Baglin TP, Huntington JA
J Biol Chem 281 35478-86 (2006)
PMID: 16973611

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133776 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Antithrombin-III Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 432 amino acids
Theoretical weight: 49.09 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01008 (Residues: 33-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand IOD 21 x IOD
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P21
Unit cell:
a: 153.83Å b: 43.71Å c: 153.93Å
α: 90° β: 120.01° γ: 90°
R-values:
R R work R free
0.225 0.225 0.239
Expression system: Cricetulus griseus

Quick links

Citations

8 review citations

Inherited antithrombin deficiency: a review.
Patnaik et al. (2008)
7 more

12 mentions without citation

Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis.
Grover et al. (2022)
11 more