› 1t1w

X-ray diffraction
2.2Å resolution

Structural basis for degenerate recognition of HIV peptide variants by cytotoxic lymphocyte, variant SL9-3F6I8V

Released:
DOI: 10.2210/pdb1t1w/pdb
PDB entry 1t1w coloured by chain, front view.
PDB entry 1t1w coloured by chain, side view.
PDB entry 1t1w coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.
Martinez-Hackert E, Anikeeva N, Kalams SA, Walker BD, Hendrickson WA, Sykulev Y
J Biol Chem 281 20205-12 (2006)
PMID: 16702212

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-126734 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Immunodeficiency lentiviral matrix N-terminal domain-containing protein Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 977 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: O11822 (Residues: 7-15; Coverage: 43%)
Gene name: gag
Sequence domains: gag gene protein p17 (matrix protein)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 55.81Å b: 80.03Å c: 57.68Å
α: 90° β: 116.21° γ: 90°
R-values:
R R work R free
0.182 0.182 0.237
Expression systems:
  • Drosophila melanogaster
  • Not provided

Quick links

Citations

5 review citations

CD 4+ T cells in the pathobiology of neurodegenerative disorders.
Huang et al. (2009)
4 more

4 mentions without citation

Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope.
Song et al. (2017)
3 more