› 1t89

X-ray diffraction
3.5Å resolution

CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (HEXAGONAL)

Released:
DOI: 10.2210/pdb1t89/pdb
PDB entry 1t89 coloured by chain, front view.
PDB entry 1t89 coloured by chain, side view.
PDB entry 1t89 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of a human type III Fcgamma receptor in complex with Fc.
Radaev S, Motyka S, Fridman WH, Sautes-Fridman C, Sun PD
J Biol Chem 276 16469-77 (2001)
PMID: 11297532

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130816 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 224 amino acids
Theoretical weight: 25.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 107-328; Coverage: 56%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Low affinity immunoglobulin gamma Fc region receptor III-B Chain: C
Molecule details ›
Chain: C
Length: 176 amino acids
Theoretical weight: 20.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75015 (Residues: 19-194; Coverage: 81%)
Gene names: CD16B, FCG3, FCGR3, FCGR3B, IGFR3
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, NDG, GAL, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, NDG, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P6522
Unit cell:
a: 114.984Å b: 114.984Å c: 301.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.247 0.309
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

73 review citations

Fcgamma receptors as regulators of immune responses.
Nimmerjahn et al. (2008)
72 more

18 mentions without citation

Human IgG4: a structural perspective.
Davies et al. (2015)
17 more