Function and Biology Details
Reaction catalysed:
A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Acyl-CoA dehydrogenase, conserved site
- Electron transfer flavoprotein, alpha/beta-subunit, N-terminal
- Acyl-CoA dehydrogenase-like, C-terminal
- Acyl-CoA dehydrogenase/oxidase, C-terminal
- Acyl-CoA oxidase/dehydrogenase, middle domain
- Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
- Acyl-CoA dehydrogenase/oxidase, N-terminal
- Medium-chain specific acyl-CoA dehydrogenase
11 more domains
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145792 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Molecule details ›
Chains: A, B, C, D
Length: 396 amino acids
Theoretical weight: 43.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 396 amino acids
Theoretical weight: 43.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P11310 (Residues: 26-421; Coverage: 94%)
Sequence domains:
- Acyl-CoA dehydrogenase, N-terminal domain
- Acyl-CoA dehydrogenase, middle domain
- Acyl-CoA dehydrogenase, C-terminal domain
Electron transfer flavoprotein subunit alpha, mitochondrial
Molecule details ›
Chain: R
Length: 333 amino acids
Theoretical weight: 35.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: HUPs
Length: 333 amino acids
Theoretical weight: 35.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P13804 (Residues: 1-333; Coverage: 100%)
Sequence domains:
Structure domains: HUPs
Electron transfer flavoprotein subunit beta
Molecule details ›
Chain: S
Length: 255 amino acids
Theoretical weight: 27.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Electron transfer flavoprotein domain
Structure domains: HUPs
Length: 255 amino acids
Theoretical weight: 27.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P38117 (Residues: 1-255; Coverage: 100%)
Sequence domains: Electron transfer flavoprotein domain
Structure domains: HUPs
