› 1tgj

X-ray diffraction
2Å resolution

HUMAN TRANSFORMING GROWTH FACTOR-BETA 3, CRYSTALLIZED FROM DIOXANE

Released:
DOI: 10.2210/pdb1tgj/pdb
PDB entry 1tgj coloured by chain, front view.
PDB entry 1tgj coloured by chain, side view.
PDB entry 1tgj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Mittl PR, Priestle JP, Cox DA, McMaster G, Cerletti N, Grütter MG
Protein Sci 5 1261-71 (1996)
PMID: 8819159

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145355 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transforming growth factor beta-3 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10600 (Residues: 301-412; Coverage: 29%)
Gene name: TGFB3
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand DIO 1 x DIO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P3221
Unit cell:
a: 49.3Å b: 49.3Å c: 78.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.175 0.175 not available
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Shi et al. (2003)
23 more

12 mentions without citation

Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
Vreven et al. (2015)
11 more