› 1tnd

X-ray diffraction
2.2Å resolution

THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S

Released:
DOI: 10.2210/pdb1tnd/pdb
PDB entry 1tnd coloured by chain, front view.
PDB entry 1tnd coloured by chain, side view.
PDB entry 1tnd coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.
Noel JP, Hamm HE, Sigler PB
Nature 366 654-63 (1993)
PMID: 8259210

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138153 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanine nucleotide-binding protein G(t) subunit alpha-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 324 amino acids
Theoretical weight: 37.14 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P04695 (Residues: 27-350; Coverage: 93%)
Gene name: GNAT1
Sequence domains: G-protein alpha subunit
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 3 x MG
Ligand CAC 6 x CAC
Ligand GSP 3 x GSP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 74.5Å b: 108.3Å c: 79Å
α: 90° β: 112.3° γ: 90°
R-values:
R R work R free
0.19 0.19 not available
Expression system: Not provided

Quick links

Citations

99 review citations

Heterotrimeric G proteins: organizers of transmembrane signals.
Neer EJ. (1995)
98 more

26 mentions without citation

Discovery of new GPCR biology: one receptor structure at a time.
Hanson et al. (2009)
25 more