› 1tr2

X-ray diffraction
2.9Å resolution

Crystal structure of human full-length vinculin (residues 1-1066)

Released:
DOI: 10.2210/pdb1tr2/pdb
PDB entry 1tr2 coloured by chain, front view.
PDB entry 1tr2 coloured by chain, side view.
PDB entry 1tr2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human vinculin.
Borgon RA, Vonrhein C, Bricogne G, Bois PR, Izard T
Structure 12 1189-97 (2004)
PMID: 15242595

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148317 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vinculin Chains: A, B
Molecule details ›
Chains: A, B
Length: 1066 amino acids
Theoretical weight: 118.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18206 (Residues: 1-1134; Coverage: 94%)
Gene name: VCL
Sequence domains: Vinculin family
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 72 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 66.74Å b: 154.08Å c: 108.95Å
α: 90° β: 90.44° γ: 90°
R-values:
R R work R free
0.236 0.232 0.3
Expression system: Escherichia coli

Quick links

Citations

16 review citations

The structure and regulation of vinculin.
Ziegler et al. (2006)
15 more

33 mentions without citation

Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins.
Lee et al. (2014)
32 more