Function and Biology Details
Reactions catalysed:
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- E2 binding
- THIF-type NAD/FAD binding fold
- ThiF/MoeB/HesA family
- Ubiquitin-activating enzyme
- Ubiquitin-activating enzyme E1, Cys active site
- Ubiquitin activating enzyme, alpha domain superfamily
- NEDD8-activating enzyme E1 catalytic subunit, N-terminal domain
- NEDD8-activating enzyme E1 regulatory subunit APP-BP1
Structure domain:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158198 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):