› 1tyr

X-ray diffraction
1.8Å resolution

TRANSTHYRETIN COMPLEX WITH RETINOIC ACID

Released:
DOI: 10.2210/pdb1tyr/pdb
PDB entry 1tyr coloured by chain, front view.
PDB entry 1tyr coloured by chain, side view.
PDB entry 1tyr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the transthyretin--retinoic-acid complex.
Zanotti G, D'Acunto MR, Malpeli G, Folli C, Berni R
Eur. J. Biochem. 234 563-9 (1995)
PMID: 8536704

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-136167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand 9CR 2 x 9CR
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 43.8Å b: 86.22Å c: 65.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 not available not available

Quick links

Citations

3 review citations

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.
Connelly et al. (2010)
2 more

13 mentions without citation

Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.
Olsen et al. (2014)
12 more