› 1tz4

Solution NMR

[hPP19-23]-pNPY bound to DPC Micelles

Released:
DOI: 10.2210/pdb1tz4/pdb
PDB entry 1tz4 coloured by chain, ensemble of 20 models, front view.
PDB entry 1tz4 coloured by chain, ensemble of 20 models, side view.
PDB entry 1tz4 coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding.
Lerch M, Kamimori H, Folkers G, Aguilar MI, Beck-Sickinger AG, Zerbe O
Biochemistry 44 9255-64 (2005)
PMID: 15966750

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134171 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuropeptide Y; Pancreatic polypeptide Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 4.17 KDa
Source organisms: Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01304 (Residues: 10-27, 35-45; Coverage: 43%)
  • Canonical: P01298 (Residues: 48-54; Coverage: 11%)
Gene names: NPY, PNP, PPY
Sequence domains: Pancreatic hormone peptide

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Torsion angle dynamics followed by refinement in AMBER6
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Survey of the year 2005 commercial optical biosensor literature.
Rich et al. (2006)
5 more

2 mentions without citation

Non-specific binding and general cross-reactivity of Y receptor agonists are correlated and should importantly depend on their acidic sectors.
Parker et al. (2011)
1 more