› 1u21

X-ray diffraction
1.69Å resolution

transthyretin with tethered inhibitor on one monomer.

Released:
DOI: 10.2210/pdb1u21/pdb
PDB entry 1u21 coloured by chain, front view.
PDB entry 1u21 coloured by chain, side view.
PDB entry 1u21 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Kinetic stabilization of an oligomeric protein by a single ligand binding event.
Wiseman RL, Johnson SM, Kelker MS, Foss T, Wilson IA, Kelly JW
J Am Chem Soc 127 5540-51 (2005)
PMID: 15826192

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand P2C 2 x P2C
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21212
Unit cell:
a: 43.654Å b: 85.643Å c: 63.925Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.217 0.239
Expression system: Escherichia coli

Quick links

Citations

12 review citations

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.
Johnson et al. (2012)
11 more

2 mentions without citation

DeepFrag: a deep convolutional neural network for fragment-based lead optimization.
Green et al. (2021)
1 more