› 1u4l

X-ray diffraction
2Å resolution

human RANTES complexed to heparin-derived disaccharide I-S

Released:
DOI: 10.2210/pdb1u4l/pdb
PDB entry 1u4l coloured by chain, front view.
PDB entry 1u4l coloured by chain, side view.
PDB entry 1u4l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors.
Shaw JP, Johnson Z, Borlat F, Zwahlen C, Kungl A, Roulin K, Harrenga A, Wells TN, Proudfoot AE
Structure 12 2081-93 (2004)
PMID: 15530372

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
C-C motif chemokine 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 68 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13501 (Residues: 24-91; Coverage: 100%)
Gene names: CCL5, D17S136E, SCYA5
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

Carbohydrate polymer : NEW Components: SGN, UAP
Carbohydrate polymer
1 bound ligand:
Ligand ACY 1 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P212121
Unit cell:
a: 24.017Å b: 56.35Å c: 94.412Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.255
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

22 review citations

Chemokine: receptor structure, interactions, and antagonism.
Allen et al. (2007)
21 more

13 mentions without citation

Chemokine oligomerization in cell signaling and migration.
Wang et al. (2013)
12 more