› 1up1

X-ray diffraction
1.9Å resolution

UP1, THE TWO RNA-RECOGNITION MOTIF DOMAIN OF HNRNP A1

Released:
DOI: 10.2210/pdb1up1/pdb
PDB entry 1up1 coloured by chain, front view.
PDB entry 1up1 coloured by chain, side view.
PDB entry 1up1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs.
Xu RM, Jokhan L, Cheng X, Mayeda A, Krainer AR
Structure 5 559-70 (1997)
PMID: 9115444

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 20.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09651 (Residues: 3-184; Coverage: 49%)
Gene names: HNRNPA1, HNRPA1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P21
Unit cell:
a: 37.99Å b: 43.94Å c: 55.75Å
α: 90° β: 94.2° γ: 90°
R-values:
R R work R free
0.197 0.197 0.254

Quick links

Citations

15 review citations

Mechanisms of alternative pre-messenger RNA splicing.
Black DL. (2003)
14 more

8 mentions without citation

Terminal loop-mediated regulation of miRNA biogenesis: selectivity and mechanisms.
Castilla-Llorente et al. (2013)
7 more