› 1upq

X-ray diffraction
1.48Å resolution

Crystal structure of the pleckstrin homology (PH) domain of PEPP1

Released:
DOI: 10.2210/pdb1upq/pdb
PDB entry 1upq coloured by chain, front view.
PDB entry 1upq coloured by chain, side view.
PDB entry 1upq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Milburn CC, Komander D, Deak M, Alessi DR, van Aalten DMF

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190614 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pleckstrin homology domain-containing family A member 4 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9H4M7 (Residues: 45-167; Coverage: 16%)
Gene names: PEPP1, PLEKHA4
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P4212
Unit cell:
a: 93.547Å b: 93.547Å c: 28.786Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 not available 0.243
Expression system: Escherichia coli BL21

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