› 1uvf

Solution NMR

Solution Structure of the structured part of the 15th Domain of LEKTI

Released:
DOI: 10.2210/pdb1uvf/pdb
PDB entry 1uvf coloured by chain, ensemble of 31 models, front view.
PDB entry 1uvf coloured by chain, ensemble of 31 models, side view.
PDB entry 1uvf coloured by chain, ensemble of 31 models, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of a chimeric LEKTI domain reveals a chameleon sequence.
Tidow H, Lauber T, Vitzithum K, Sommerhoff CP, Rösch P, Marx UC
Biochemistry 43 11238-47 (2004)
PMID: 15366933

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192495 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease inhibitor Kazal-type 5 Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQ38 (Residues: 989-1047; Coverage: 6%)
Gene name: SPINK5
Sequence domains: Kazal-type serine protease inhibitor domain
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases.
Uversky et al. (2014)
1 more

2 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
1 more