› 1uwo

Solution NMR

CALCIUM FORM OF HUMAN S100B, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1uwo/pdb
PDB entry 1uwo coloured by chain, ensemble of 20 models, front view.
PDB entry 1uwo coloured by chain, ensemble of 20 models, side view.
PDB entry 1uwo coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form.
Smith SP, Shaw GS
Structure 6 211-22 (1998)
PMID: 9519411

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137551 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-B Chains: A, B
Molecule details ›
Chains: A, B
Length: 91 amino acids
Theoretical weight: 10.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04271 (Residues: 2-92; Coverage: 99%)
Gene name: S100B
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: HYBRID DISTANCE GEOMETRY AND SIMULATED ANNEALING
Expression system: Escherichia coli

Quick links

Citations

11 review citations

S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.
Donato R. (2001)
10 more

11 mentions without citation

In silico structure-based approaches to discover protein-protein interaction-targeting drugs.
Shin et al. (2017)
10 more