› 1uzj

X-ray diffraction
2.25Å resolution

Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, holo form.

Released:
DOI: 10.2210/pdb1uzj/pdb
PDB entry 1uzj coloured by chain, front view.
PDB entry 1uzj coloured by chain, side view.
PDB entry 1uzj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization.
Lee SS, Knott V, Jovanović J, Harlos K, Grimes JM, Choulier L, Mardon HJ, Stuart DI, Handford PA
Structure 12 717-29 (2004)
PMID: 15062093

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152940 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibrillin-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 162 amino acids
Theoretical weight: 17.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35555 (Residues: 1486-1647; Coverage: 6%)
Gene names: FBN, FBN1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P21
Unit cell:
a: 43.1Å b: 105.6Å c: 65Å
α: 90° β: 104.2° γ: 90°
R-values:
R R work R free
0.247 0.247 0.318
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability.
Rifkin DB. (2005)
20 more

8 mentions without citation

Mutations in the TGFβ binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias.
Le Goff et al. (2011)
7 more