› 1v59

X-ray diffraction
2.2Å resolution

Crystal structure of yeast lipoamide dehydrogenase complexed with NAD+

Released:
DOI: 10.2210/pdb1v59/pdb
PDB entry 1v59 coloured by chain, front view.
PDB entry 1v59 coloured by chain, side view.
PDB entry 1v59 coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Entry authors: Adachi W, Suzuki K, Tsunoda M, Sekiguchi T, Reed LJ, Takenaka A

Function and Biology Details

Reaction catalysed: 
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140719 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydrolipoyl dehydrogenase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 478 amino acids
Theoretical weight: 51.62 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P09624 (Residues: 22-499; Coverage: 96%)
Gene names: DHLP1, LPD1, YFL018C
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD

Cofactor: Ligand NAD 2 x NAD
1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P212121
Unit cell:
a: 66.6Å b: 96.4Å c: 160.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.246

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