› 1vbt

X-ray diffraction
2.3Å resolution

Structure of cyclophilin complexed with sulfur-substituted tetrapeptide AAPF

Released:
DOI: 10.2210/pdb1vbt/pdb
PDB entry 1vbt coloured by chain, front view.
PDB entry 1vbt coloured by chain, side view.
PDB entry 1vbt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhao Y, Chen Y, Schutkowski M, Fischer G, Ke H

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158788 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase A Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62937 (Residues: 2-165; Coverage: 99%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
SULFUR-SUBSTITUTED TETRAPEPTIDE Chains: C, D
Molecule details ›
Chains: C, D
Length: 5 amino acids
Theoretical weight: 541 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ALT 2 x ALT

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 37.7Å b: 109.1Å c: 118.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.246
Expression systems:
  • Escherichia coli
  • Not provided

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