› 1vpp

X-ray diffraction
1.9Å resolution

COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE

Released:
DOI: 10.2210/pdb1vpp/pdb
PDB entry 1vpp coloured by chain, front view.
PDB entry 1vpp coloured by chain, side view.
PDB entry 1vpp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Wiesmann C, Christinger HW, Cochran AG, Cunningham BC, Fairbrother WJ, Keenan CJ, Meng G, de Vos AM
Biochemistry 37 17765-72 (1998)
PMID: 9922142

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147434 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N-VEGF Chains: V, W
Molecule details ›
Chains: V, W
Length: 102 amino acids
Theoretical weight: 11.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15692 (Residues: 214-315; Coverage: 26%)
Gene names: VEGF, VEGFA
Sequence domains: VEGF heparin-binding domain
Structure domains: Cystine-knot cytokines
PROTEIN (PEPTIDE V108) Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 20 amino acids
Theoretical weight: 2.26 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 47.703Å b: 74.661Å c: 79.883Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.27
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

10 review citations

The process of structure-based drug design.
Anderson AC. (2003)
9 more

5 mentions without citation

A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics.
Ye et al. (2021)
4 more