› 1vr2

X-ray diffraction
2.4Å resolution

HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (KDR) KINASE DOMAIN

Released:
DOI: 10.2210/pdb1vr2/pdb
PDB entry 1vr2 coloured by chain, front view.
PDB entry 1vr2 coloured by chain, side view.
PDB entry 1vr2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.
McTigue MA, Wickersham JA, Pinko C, Showalter RE, Parast CV, Tempczyk-Russell A, Gehring MR, Mroczkowski B, Kan CC, Villafranca JE, Appelt K
Structure 7 319-30 (1999)
PMID: 10368301

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.27 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35968 (Residues: 806-1171; Coverage: 24%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 95.41Å b: 96.04Å c: 38.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 not available
Expression system: Spodoptera frugiperda

Quick links

Citations

17 review citations

Regulation of protein kinases; controlling activity through activation segment conformation.
Nolen et al. (2004)
16 more

25 mentions without citation

Developing irreversible inhibitors of the protein kinase cysteinome.
Liu et al. (2013)
24 more