› 1w22

X-ray diffraction
2.5Å resolution

Function and Biology Details

Reaction catalysed: 
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189815 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone deacetylase 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 377 amino acids
Theoretical weight: 41.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9BY41 (Residues: 1-377; Coverage: 100%)
Gene names: CDA07, HDAC8, HDACL1
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand K 4 x K
Ligand NHB 2 x NHB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P21
Unit cell:
a: 51.746Å b: 83.532Å c: 94.653Å
α: 90° β: 97.48° γ: 90°
R-values:
R R work R free
0.21 0.21 0.25
Expression system: Escherichia coli BL21

Quick links

Citations

112 review citations

Anticancer activities of histone deacetylase inhibitors.
Bolden et al. (2006)
111 more

29 mentions without citation

HDAC8 substrates: Histones and beyond.
Wolfson et al. (2013)
28 more