› 1w4m

Solution NMR

Structure of the human pleckstrin DEP domain by multidimensional NMR

Released:
DOI: 10.2210/pdb1w4m/pdb
PDB entry 1w4m coloured by chain, ensemble of 10 models, front view.
PDB entry 1w4m coloured by chain, ensemble of 10 models, side view.
PDB entry 1w4m coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily.
Civera C, Simon B, Stier G, Sattler M, Macias MJ
Proteins 58 354-66 (2005)
PMID: 15573383

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140179 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pleckstrin Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 11.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08567 (Residues: 121-223; Coverage: 29%)
Gene names: P47, PLEK
Sequence domains: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions.
Michell et al. (2006)
2 more

4 mentions without citation

Emerging Roles of Pleckstrin-2 Beyond Cell Spreading.
Wang et al. (2021)
3 more