› 1wip

X-ray diffraction
4Å resolution

STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4, MONOCLINIC CRYSTAL FORM

Released:
DOI: 10.2210/pdb1wip/pdb
PDB entry 1wip coloured by chain, front view.
PDB entry 1wip coloured by chain, side view.
PDB entry 1wip coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Dimeric association and segmental variability in the structure of human CD4.
Wu H, Kwong PD, Hendrickson WA
Nature 387 527-30 (1997)
PMID: 9168119

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134521 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell surface glycoprotein CD4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 363 amino acids
Theoretical weight: 40.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01730 (Residues: 26-388; Coverage: 84%)
Gene name: CD4
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P2
Unit cell:
a: 100.5Å b: 123.4Å c: 100.6Å
α: 90° β: 103.4° γ: 90°
R-values:
R R work R free
0.452 0.452 0.427

Quick links

Citations

46 review citations

How TCRs bind MHCs, peptides, and coreceptors.
Rudolph et al. (2006)
45 more

11 mentions without citation

HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth.
Acharya et al. (2015)
10 more