› 1wu3

X-ray diffraction
2.15Å resolution

Crystal structure of recombinant murine interferon beta

Released:
DOI: 10.2210/pdb1wu3/pdb
PDB entry 1wu3 coloured by chain, front view.
PDB entry 1wu3 coloured by chain, side view.
PDB entry 1wu3 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Refined crystal structure of recombinant murine interferon-beta at 2.15 A resolution.
Senda T, Saitoh S, Mitsui Y
J Mol Biol 253 187-207 (1995)
PMID: 7473712

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134398 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon beta Chain: I
Molecule details ›
Chain: I
Length: 161 amino acids
Theoretical weight: 19.76 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01575 (Residues: 22-182; Coverage: 100%)
Gene names: Ifb, Ifnb, Ifnb1
Sequence domains: Interferon alpha/beta domain
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P65
Unit cell:
a: 71.4Å b: 71.4Å c: 79.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.192 0.247
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Interferons, interferon-like cytokines, and their receptors.
Pestka et al. (2004)
6 more

3 mentions without citation

The Role of Structure in the Biology of Interferon Signaling.
Walter MR. (2020)
2 more