› 1wwa

X-ray diffraction
2.5Å resolution

NGF BINDING DOMAIN OF HUMAN TRKA RECEPTOR

Released:
DOI: 10.2210/pdb1wwa/pdb
PDB entry 1wwa coloured by chain, front view.
PDB entry 1wwa coloured by chain, side view.
PDB entry 1wwa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
Ultsch MH, Wiesmann C, Simmons LC, Henrich J, Yang M, Reilly D, Bass SH, de Vos AM
J Mol Biol 290 149-59 (1999)
PMID: 10388563

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-138088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
High affinity nerve growth factor receptor Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 109 amino acids
Theoretical weight: 12.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04629 (Residues: 278-386; Coverage: 14%)
Gene names: MTC, NTRK1, TRK, TRKA
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P41212
Unit cell:
a: 106.42Å b: 106.42Å c: 75.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.258
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Neurotrophins: roles in neuronal development and function.
Huang et al. (2001)
29 more

9 mentions without citation

Open interface and large quaternary structure movements in 3D domain swapped proteins: insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease A.
Merlino et al. (2005)
8 more