› 1wwb

X-ray diffraction
2.1Å resolution

LIGAND BINDING DOMAIN OF HUMAN TRKB RECEPTOR

Released:
DOI: 10.2210/pdb1wwb/pdb
PDB entry 1wwb coloured by chain, front view.
PDB entry 1wwb coloured by chain, side view.
PDB entry 1wwb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
Ultsch MH, Wiesmann C, Simmons LC, Henrich J, Yang M, Reilly D, Bass SH, de Vos AM
J Mol Biol 290 149-59 (1999)
PMID: 10388563

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172527 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BDNF/NT-3 growth factors receptor Chain: X
Molecule details ›
Chain: X
Length: 103 amino acids
Theoretical weight: 11.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16620 (Residues: 283-385; Coverage: 13%)
Gene names: NTRK2, TRKB
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P6422
Unit cell:
a: 68.34Å b: 68.34Å c: 124.34Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.247 0.297
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Neurotrophins: roles in neuronal development and function.
Huang et al. (2001)
29 more

12 mentions without citation

Protein-protein docking benchmark version 4.0.
Hwang et al. (2010)
11 more