Function and Biology Details
Reaction catalysed:
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Uracil DNA glycosylase family 2
- Ubiquitin-like domain
- Uracil-DNA glycosylase-like domain superfamily
- Rad60/SUMO-like domain
- Small ubiquitin-related modifier 1, Ubl domain
- Ubiquitin-like domain superfamily
- Uracil-DNA glycosylase-like
- G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotes
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159017 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
G/T mismatch-specific thymine DNA glycosylase
Molecule details ›
Chain: A
Length: 230 amino acids
Theoretical weight: 26.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Uracil DNA glycosylase superfamily
Structure domains: Uracil-DNA glycosylase-like domain
Length: 230 amino acids
Theoretical weight: 26.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q13569 (Residues: 112-339; Coverage: 56%)
Sequence domains: Uracil DNA glycosylase superfamily
Structure domains: Uracil-DNA glycosylase-like domain
Small ubiquitin-related modifier 1
Molecule details ›
Chain: B
Length: 97 amino acids
Theoretical weight: 11.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Ubiquitin-2 like Rad60 SUMO-like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Length: 97 amino acids
Theoretical weight: 11.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P63165 (Residues: 1-97; Coverage: 96%)
Sequence domains: Ubiquitin-2 like Rad60 SUMO-like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
