› 1x11

X-ray diffraction
2.5Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
hetero octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-138396 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Amyloid-beta A4 precursor protein-binding family A member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 172 amino acids
Theoretical weight: 19.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02410 (Residues: 453-623; Coverage: 20%)
Gene names: APBA1, MINT1, X11
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
C31 Chains: C, D
Molecule details ›
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.64 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 754-766; Coverage: 2%)
Gene names: A4, AD1, APP

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 18 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P41212
Unit cell:
a: 74.6Å b: 74.6Å c: 155.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.304
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

28 review citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains.
Lemmon et al. (2000)
27 more

11 mentions without citation

Classification of intrinsically disordered regions and proteins.
van der Lee et al. (2014)
10 more