› 1x51

Solution NMR

Solution structure of the NUDIX domain from human A/G-specific adenine DNA glycosylase alpha-3 splice isoform

Released:
DOI: 10.2210/pdb1x51/pdb
PDB entry 1x51 coloured by chain, ensemble of 20 models, front view.
PDB entry 1x51 coloured by chain, ensemble of 20 models, side view.
PDB entry 1x51 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Tomizawa T, Kigawa T, Koshiba S, Inoue M, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193782 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenine DNA glycosylase Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 16.84 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UIF7 (Residues: 356-497; Coverage: 26%)
Gene names: MUTYH, MYH
Sequence domains: NUDIX domain
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, restrainted molecular dynamics
Expression system: Not provided

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