› 1x6c

Solution NMR

Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1

Released:
DOI: 10.2210/pdb1x6c/pdb
PDB entry 1x6c coloured by chain, ensemble of 20 models, front view.
PDB entry 1x6c coloured by chain, ensemble of 20 models, side view.
PDB entry 1x6c coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Sato M, Koshiba S, Inoue M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151411 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 6 Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P29350 (Residues: 110-214; Coverage: 18%)
Gene names: HCP, PTP1C, PTPN6
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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