› 1x88

X-ray diffraction
1.8Å resolution

Human Eg5 motor domain bound to Mg-ADP and monastrol

Released:
DOI: 10.2210/pdb1x88/pdb
PDB entry 1x88 coloured by chain, front view.
PDB entry 1x88 coloured by chain, side view.
PDB entry 1x88 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Maliga Z, Mitchison TJ

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 359 amino acids
Theoretical weight: 40.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52732 (Residues: 10-368; Coverage: 34%)
Gene names: EG5, KIF11, KNSL1, TRIP5
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

3 bound ligands:
Ligand MG 2 x MG
Ligand ADP 2 x ADP
Ligand NAT 2 x NAT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 69.706Å b: 79.648Å c: 159.451Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.225
Expression system: Escherichia coli BL21(DE3)

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