› 1xa5

X-ray diffraction
2.12Å resolution

Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid

Released:
DOI: 10.2210/pdb1xa5/pdb
PDB entry 1xa5 coloured by chain, front view.
PDB entry 1xa5 coloured by chain, side view.
PDB entry 1xa5 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug.
Horváth I, Harmat V, Perczel A, Pálfi V, Nyitray L, Nagy A, Hlavanda E, Náray-Szabó G, Ovádi J
J Biol Chem 280 8266-74 (2005)
PMID: 15596444

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158581 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P62157 (Residues: 2-149; Coverage: 99%)
Gene names: CALM, CAM
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand KAR 1 x KAR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P6122
Unit cell:
a: 37.573Å b: 37.573Å c: 356.662Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.218 0.261

Quick links

Citations

3 review citations

The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer.
Berchtold et al. (2014)
2 more

5 mentions without citation

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database.
Wang et al. (2017)
4 more