› 1xap

X-ray diffraction
2.1Å resolution

Structure of the ligand binding domain of the Retinoic Acid Receptor beta

Released:
DOI: 10.2210/pdb1xap/pdb
PDB entry 1xap coloured by chain, front view.
PDB entry 1xap coloured by chain, side view.
PDB entry 1xap coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Rational design of RAR-selective ligands revealed by RARbeta crystal stucture.
Germain P, Kammerer S, Pérez E, Peluso-Iltis C, Tortolani D, Zusi FC, Starrett J, Lapointe P, Daris JP, Marinier A, de Lera AR, Rochel N, Gronemeyer H
EMBO Rep 5 877-82 (2004)
PMID: 15319780

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145476 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor beta Chain: A
Molecule details ›
Chain: A
Length: 267 amino acids
Theoretical weight: 30.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10826 (Residues: 176-421; Coverage: 54%)
Gene names: HAP, NR1B2, RARB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand TTB 1 x TTB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 47.276Å b: 57.808Å c: 90.289Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.253
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Principles for modulation of the nuclear receptor superfamily.
Gronemeyer et al. (2004)
13 more

11 mentions without citation

Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids.
Eroglu et al. (2013)
10 more