› 1xaw

X-ray diffraction
1.45Å resolution

crystal structure of the cytoplasmic distal C-terminal domain of occludin

Released:
DOI: 10.2210/pdb1xaw/pdb
PDB entry 1xaw coloured by chain, front view.
PDB entry 1xaw coloured by chain, side view.
PDB entry 1xaw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface.
Li Y, Fanning AS, Anderson JM, Lavie A
J Mol Biol 352 151-64 (2005)
PMID: 16081103

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172531 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Occludin Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 16.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16625 (Residues: 383-522; Coverage: 27%)
Gene name: OCLN
Sequence domains: Occludin homology domain
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: C2221
Unit cell:
a: 46.96Å b: 109.57Å c: 48.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.275 0.261 0.284
Expression system: Escherichia coli

Quick links

Citations

29 review citations

Epithelial barriers in homeostasis and disease.
Marchiando et al. (2010)
28 more

5 mentions without citation

Structural Features of Tight-Junction Proteins.
Heinemann et al. (2019)
4 more