› 1xca

X-ray diffraction
2.3Å resolution

APO-CELLULAR RETINOIC ACID BINDING PROTEIN II

Released:
DOI: 10.2210/pdb1xca/pdb
PDB entry 1xca coloured by chain, front view.
PDB entry 1xca coloured by chain, side view.
PDB entry 1xca coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of apo-cellular retinoic acid-binding protein type II (R111M) suggests a mechanism of ligand entry.
Chen X, Tordova M, Gilliland GL, Wang L, Li Y, Yan H, Ji X
J Mol Biol 278 641-53 (1998)
PMID: 9600845

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular retinoic acid-binding protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 137 amino acids
Theoretical weight: 15.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29373 (Residues: 2-138; Coverage: 99%)
Gene name: CRABP2
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-D
Spacegroup: P1
Unit cell:
a: 37.58Å b: 62.27Å c: 35.12Å
α: 106.41° β: 90.69° γ: 110.64°
R-values:
R R work R free
0.18 0.18 0.282
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Retinoid-binding proteins: mediators of retinoid action.
Noy N. (2000)
1 more

3 mentions without citation

Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding.
Vaezeslami et al. (2008)
2 more