› 1xed

X-ray diffraction
1.9Å resolution

Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR

Released:
DOI: 10.2210/pdb1xed/pdb
PDB entry 1xed coloured by chain, front view.
PDB entry 1xed coloured by chain, side view.
PDB entry 1xed coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor.
Hamburger AE, West AP, Bjorkman PJ
Structure 12 1925-35 (2004)
PMID: 15530357

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-134608 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Secretory component Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 117 amino acids
Theoretical weight: 12.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01833 (Residues: 19-127; Coverage: 15%)
Gene name: PIGR
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 41.996Å b: 157.195Å c: 53.86Å
α: 90° β: 112.94° γ: 90°
R-values:
R R work R free
0.183 0.183 0.244
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

The function of immunoglobulin A in immunity.
Woof et al. (2006)
15 more

4 mentions without citation

Assessing the accuracy of octanol-water partition coefficient predictions in the SAMPL6 Part II log P Challenge.
Işık et al. (2020)
3 more