› 1xks

X-ray diffraction
2.35Å resolution

The crystal structure of the N-terminal domain of Nup133 reveals a beta-propeller fold common to several nucleoporins

Released:
DOI: 10.2210/pdb1xks/pdb
PDB entry 1xks coloured by chain, front view.
PDB entry 1xks coloured by chain, side view.
PDB entry 1xks coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex.
Berke IC, Boehmer T, Blobel G, Schwartz TU
J Cell Biol 167 591-7 (2004)
PMID: 15557116

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear pore complex protein Nup133 Chain: A
Molecule details ›
Chain: A
Length: 450 amino acids
Theoretical weight: 48.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WUM0 (Residues: 67-514; Coverage: 39%)
Gene name: NUP133
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P43212
Unit cell:
a: 84.588Å b: 84.588Å c: 139.048Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.196 0.236
Expression system: Escherichia coli

Quick links

Citations

23 review citations

The nuclear pore complex and nuclear transport.
Wente et al. (2010)
22 more

19 mentions without citation

The Structure of the Nuclear Pore Complex (An Update).
Lin et al. (2019)
18 more