› 1xni

X-ray diffraction
2.8Å resolution

Tandem Tudor Domain of 53BP1

Released:
DOI: 10.2210/pdb1xni/pdb
PDB entry 1xni coloured by chain, front view.
PDB entry 1xni coloured by chain, side view.
PDB entry 1xni coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.
Huyen Y, Zgheib O, Ditullio RA, Gorgoulis VG, Zacharatos P, Petty TJ, Sheston EA, Mellert HS, Stavridi ES, Halazonetis TD
Nature 432 406-11 (2004)
PMID: 15525939

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171424 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TP53-binding protein 1 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 118 amino acids
Theoretical weight: 13.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q12888 (Residues: 1485-1602; Coverage: 6%)
Gene name: TP53BP1
Sequence domains: Tumour suppressor p53-binding protein-1 Tudor
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 71.61Å b: 157.664Å c: 179.723Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.247 0.269
Expression system: Escherichia coli BL21

Quick links

Citations

216 review citations

Chromatin modifications and their function.
Kouzarides T. (2007)
215 more

8 mentions without citation

A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair.
Bártová et al. (2019)
7 more