› 1xtk

X-ray diffraction
2.4Å resolution

structure of DECD to DEAD mutation of human UAP56

Released:
DOI: 10.2210/pdb1xtk/pdb
PDB entry 1xtk coloured by chain, front view.
PDB entry 1xtk coloured by chain, side view.
PDB entry 1xtk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human ATP-dependent splicing and export factor UAP56.
Shi H, Cordin O, Minder CM, Linder P, Xu RM
Proc Natl Acad Sci U S A 101 17628-33 (2004)
PMID: 15585580

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spliceosome RNA helicase DDX39B Chain: A
Molecule details ›
Chain: A
Length: 390 amino acids
Theoretical weight: 44.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13838 (Residues: 45-428; Coverage: 90%)
Gene names: BAT1, DDX39B, UAP56
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand BME 1 x BME
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X26C
Spacegroup: P1
Unit cell:
a: 37.432Å b: 49.756Å c: 62.805Å
α: 95.57° β: 101.93° γ: 110.89°
R-values:
R R work R free
0.25 0.25 0.3
Expression system: Escherichia coli

Quick links

Citations

21 review citations

The DEAD-box protein family of RNA helicases.
Cordin et al. (2006)
20 more

4 mentions without citation

Crystal structure of the human ATP-dependent splicing and export factor UAP56.
Shi et al. (2004)
3 more